Riding Into the Sunset

Riding Kar9 into the bud

arly endosomes may help to create their own short-range tracks, according to a report from Stéphane Gasman, Yannis Kalaidzidis, and Marino Zerial (Max Planck Institute, Dresden, Germany). The results also suggest parallels between membrane trafficking, signaling, and regulation of the cytoskeleton. Trafficking of early endosomes requires the small GTPase RhoD. Zerial’s group identified the firs...

Riding the R Train into the Cell

1 Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America, 2 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, 3 Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, United States of America, 4 Yale Cancer Center, New Haven, Connecticut, United States ...

Driving into the Sunset: Supporting Cognitive Functioning in Older Drivers

The rise in the aging driver population presents society with a significant challenge-how to maintain safety and mobility on the roads. On the one hand, older drivers pose a higher risk of an at-fault accident on a mile-for-mile basis; on the other hand, independent mobility is a significant marker of quality of life in aging. In this paper, we review the respective literatures on cognitive neu...

An Eclipse before Sunset

Mountain Village at Sunset.

During my travels to numerous countries over 40 years, I have seen many picturesque mountain villages with elegant and well-preserved houses perched on carefully selected sites on the mountains, and others located by a river or lake at the foot of a mountain. They appear remarkably harmonious with the natural scenery. Fruit trees or tea trees and crops such as rice, wheat, and corn are planted ...